Analysis of gut microbial regulation of host gene expression along the length of the gut and regulation of gut microbial ecology through MyD88

The Wallenberg Laboratory for Cardiovascular Research/Group Fredrik Bäckhed
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Sample information

Gene expression in four sections of the gut and three additional tisues was surveyed using DNA microarrays in germ-free and conventionally raised mice. To investigate the role of toll-like receceptor signaling, both wild-type and Myd88 mutant mice were used. The data presented on this supplementary website is based on 130 Affymetrix Gene 1.0ST microarray hybridzations. The number of replicates for each experimental group is shown in the table below.

Duodenum Jejunum Ileum Colon Liver Epi fat Sub-q fat
CONV-R, Myd88 +/+ 5 4 5 5 5 5 4
CONV-R, Myd88 -/- 5 5 5 5 5 3 5
GF, Myd88 +/+ 2 4 4 4 3 4 4
GF, Myd88 -/- 6 6 6 6 6 5 4


Principal components analysis


Inquiries can be addressed to fredrik.backhed@wlab.gu.se