Analysis of gut microbial regulation of host gene expression along the length of the gut and regulation of gut microbial ecology through MyD88

The Wallenberg Laboratory for Cardiovascular Research/Group Fredrik Bäckhed
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Welcome to the encyclopedia of microbiota regulated genes, which is presented in detail in Larsson et al. The gut microbiota is central in regulating local inflammatory and immune processes within the gut, but is also implicated in peripheral autoimmune and metabolic diseases. We have compared the transcriptional profiles of germ-free and conventionally raised mice to determine host responses to the gut microbiota in proximal, mid, and distal small intestine, and colon. This web supplement also contains additional expression data from liver, epididymal and subcutaneous white adipose tissue. To investigate the role of Toll-like receptor signaling in mediating these responses we analyzed the transcriptome of germ-free and conventionally raised Myd88-/- mice. Above you can query the database for the expression pattern of specific genes in different organs or filter genes under gene filter for the most significant changes in a given organ.

Inquiries can be addressed to fredrik.backhed@wlab.gu.se